Somatic hypermutation of the B cell receptor genes B29 (Ig , CD79b) and mb1 (Ig , CD79a)
نویسندگان
چکیده
منابع مشابه
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).
Somatic hypermutation (SHM), coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B cell maturation. SHM is known to affect Bcl6, four additional oncogenes in diffuse large B cell lymphoma, and the CD95Fas gene and is regarded as a major mechanism of B cell tumorigenesis. We find that mutations in the genes encoding the B cell receptor (BCR) accessory ...
متن کاملB cell receptor engagement and T cell contact induce Bcl-6 somatic hypermutation in human B cells: identity with Ig hypermutation.
The human bcl-6 proto-oncogene has been found to be mutated in both neoplastic and normal B cells. We used CL-01 cells, our monoclonal model of germinal center differentiation, and normal human B cells to explore the induction requirements and the modalities of bcl-6 hypermutation. As we have previously shown, CL-01 cells are IgM+ IgD+ and effectively mutate the expressed Ig VHDJH and V lambda ...
متن کاملNormal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase.
The hypermutation cascade in Ig V genes can be initiated by deamination of cytosine in DNA to uracil by activation-induced cytosine deaminase and its removal by uracil-DNA glycosylase. To determine whether damage to guanine also contributes to hypermutation, we examined the glycosylase that removes oxidized guanine from DNA, 8-hydroxyguanine-DNA glycosylase (OGG1). OGG1 has been reported to be ...
متن کاملB - Cell Antigen Receptor – Induced Apoptosis Requires Both Ig a and Ig b
The response of a B cell to antigen is dependent on the and then aggregate dimers, representative of partial recepsurface expression of a clonotypic B-cell receptor complex tor complexes, which contained either Iga alone, Igb alone, (BCR) consisting of membrane-bound Ig and disulfide-linked or the two chains together and then examine their ability heterodimers of Iga/b. Studies of Iga or Igb ha...
متن کاملGenome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma
The processes of somatic hypermutation (SHM) and class switch recombination introduced by activation-induced cytosine deaminase (AICDA) at the Immunoglobulin (Ig) loci are key steps for creating a pool of diversified antibodies in germinal center B cells (GCBs). Unfortunately, AICDA can also accidentally introduce mutations at bystander loci, particularly within the 5' regulatory regions of pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0735266100